Diet is known to have an important impact on cardiovascular health. n-3 fatty acids, found in high quantity in fish oil, have demonstrated beneficial effects in patients with coronary artery disease. The role of n-6 fatty acids remains more controversial. The objective of this study was to examine the effect of arachidonic acid (AA), an n-6 FA, and eicosapentanoic acid (EPA), an n-3 FA, on the interaction between monocytes and endothelial cells.
Scientists conclude that AA increases inflammation and enhances the ability of endothelial cells to bind monocytes in vitro. EPA leads to a decrease in the ability of EA.hy.926 to bind monocytes, although the effect appears more modest. Taken together, these data indicate that the n-6 FA AA could potentiate inflammation and early events of atherosclerosis.