Arachidonic acid leads to atherosclerosis

Diet is known to have an important impact on cardiovascular health. n-3 fatty acids, found in high quantity in fish oil, have demonstrated beneficial effects in patients with coronary artery disease.

The role of n-6 fatty acids remains more controversial.

Scientists concluded that AA increases inflammation and enhances the ability of endothelial cells to bind monocytes in vitro. EPA leads to a decrease in the ability of EA.hy.926 to bind monocytes, although the effect appears more modest.

Taken together, data indicate that the n-6 FA AA could potentiate inflammation and early events of atherosclerosis.

Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion.
Grenon SM1, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M.
J Surg Res. 2012 Sep;177(1):e35-43. doi: 10.1016/j.jss.2012.04.010. Epub 2012 Apr 27

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